Neomycin and polymyxin b sulfates and hydrocortisone ophthalmic suspension

Neomycin/polymyxin B/hydrocortisone

Combination ofNeomycinPolymyxin BHydrocortisoneClinical dataTrade namesAHFS/Drugs.comRoutes of
administrationATC codeLegal statusLegal statusIdentifiersCAS NumberKEGG

Antibiotic

Glucocorticoid

Otosporin, Cortisporin, others

FDA Professional Drug Information

Ear drop

None

US: ℞-only [1]

8024-64-4

D11855

Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders.[2][3] It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone.[3] It is used as an ear drop or eye drop.[2][3]

The most common side effects include itchiness and a skin rash.[4] Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache.[2][4] Safety in pregnancy and breastfeeding is unclear.[5] The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.[6]

The combination was approved for medical use in the United States in 1964.[3] In 2019, it was the 329th most commonly prescribed medication in the United States, with more than nine hundred thousand prescriptions.[7]

History[edit]

Cortisporin was developed by Glaxo Wellcome and was approved by the US Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.[8]

Society and culture[edit]

Economics[edit]

In 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144.[8] The drug is owned by Dublin, Ireland-based Endo International.

References[edit]

^ "Neomycin and Polymyxin B Sulfates and Hydrocortisone- neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". DailyMed. 22 April 2019. Retrieved 22 June 2022.
^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
^ a b c d "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
^ a b "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
^ "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
^ "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019.
^ "Neomycin; Polymyxin B; Hydrocortisone - Drug Usage Statistics". ClinCalc. Retrieved 16 October 2021.
^ a b David L (4 February 2016). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". Los Angeles Times. Retrieved 5 February 2016.

External links[edit]

"Hydrocortisone acetate mixture with neomycin sulfate and polymyxin B sulfate". Drug Information Portal. U.S. National Library of Medicine.

Ocular allergy/inflammation:

For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists.

Adult Dosage:

1 or 2 drops in affected eye(s) every 3 or 4 hours, depending on severity. Max initial ℞: 20mL; do not refill without further evaluation.

Children Dosage:

Not established.

Hydrocortisone/Neomycin/Polymyxin B Ophthalmic Suspension Contraindications:

Ocular fungal, viral or mycobacterial infections.

Hydrocortisone/Neomycin/Polymyxin B Ophthalmic Suspension Warnings/Precautions:

Do not inject into the eye. Corneal or scleral thinning. Glaucoma. Monitor IOP, and for secondary infections in prolonged use. Discontinue if sensitization reaction occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.

Hydrocortisone/Neomycin/Polymyxin B Ophthalmic Suspension Classification:

Antibiotics + steroid.

Adverse Reactions:

Local irritation, sensitization (itching, swelling, conjunctival erythema), masks infection, delays healing; in prolonged use: increased IOP, cataracts, corneal perforation, optic nerve damage.

Note:

Formerly known under the brand name Cortisporin Ophthalmic.

How Supplied:

Contact supplier.

What is neomycin and polymyxin B sulfates hydrocortisone Ophthalmic Suspension USP used for?

Neomycin, polymyxin B, and hydrocortisone is a combination antibiotic and cortisone-like medicine. It is used to treat infections of the eye and to help provide relief from redness, irritation, and discomfort of certain eye problems. It is also used to help prevent permanent damage of certain eye problems.

What is neomycin and polymyxin B sulfates used to treat?

Description and Brand Names Neomycin, polymyxin B, and dexamethasone combination is used to treat eye infections and inflammation, including conjunctivitis and chronic anterior uveitis. It also prevents damage caused by chemicals, radiation, or foreign objects entering the eye.

How long does it take for neomycin and polymyxin to work?

Hydrocortisone - neomycin - polymyxin B ear drops are used to treat certain bacterial infections of the outer ear canal. This medication should start to work within 48 hours.

What is the side effects of neomycin and polymyxin and hydrocortisone?

Incidence not known.

Blood in the urine..

change in the frequency of urination or amount of urine..

difficulty in breathing..

drowsiness..

feeling of fullness in the ears..

increased thirst..

loss of balance..

loss of hearing..