High blood pressure or hypertension affects one in three adults. The symptoms are usually unnoticeable while it increases a person’s risk of heart diseases and strokes. It is also known as the silent killer.
Although, high blood pressure can easily be avoided with a few lifestyle amendments. Maintaining a healthy diet is one of the key attributes to keeping blood pressure levels at a healthy level. Garlic is known to cut high blood pressure levels by 10%. So being savvy about your food picks will help you manage and prevent heart related hypertension issues short term and long term.
Does Garlic Lower Blood Pressure?
Garlic is more than just a zest of flavour for your food and drinks. It boosts nitric oxide levels in your body, which is responsible for widening the blood vessels. The more relaxed the blood vessels are the less the heart has to work in trying to pump enough blood through the arteries- keeping blood pressure at a healthy level.
The main active ingredient in garlic is allicin. Allicin is responsible for helping keep the blood pressure levels low by preventing angiotensin II.The component that is known to cause the blood vessels to contract or tighten up-and eventually cause hypertension.
By preventing angiotensin II, it makes it extremely easy for the effects of allicin to make blood flow more easily through your arteries and increase the production of compounds that lead to improved vascular flexibility and reduced stiffness.
Experts have also mentioned and believe that the anti inflammatory and antioxidant properties have a direct correlation and contribute to reducing and preventing increased blood pressure levels.
How Much Garlic Should I Take For High Blood Pressure?
The best way to take garlic is fresh or in a powder form. Alliinase is an enzyme contained in garlic. It’s released when we crush, cut or chew raw garlic and then goes through a series of reactions resulting in the creation of allicin. The intake of cooked garlic won’t be useful because many of the positive properties needed to reduce blood pressure get destroyed. Below we discuss the amount of garlic that is needed to help reduce high blood pressure.
1. Raw Garlic
As mentioned, eating raw garlic will activate Allina that will begin to release allicin in abundance. It’s best to consume garlic within an hour or two of activating allicin. You can eat this regularly (400mg daily) and keep track of your blood pressure levels using the 24/7 blood pressure monitor from Aktiia.
2. Garlic Powder
Taking 600 to 900 mg of garlic powder will reduce hypertension by 9-12%. A dose of 600 mg will contain 3.6mg of allicin and 900mg has 5.4 mg of allicin.
3. Salads
You can add slices or minced fresh garlic to any salad of your choice. The amount really is up to you and your taste buds. Not only will it add wonderful flavour to your salad, but it will help reduce hypertension levels.
4. Garlic Milk
Peel and mince 10 to 12 garlic cloves and add them to warm milk. You can add a spoonful of honey to add a sweet taste and help digest the drink better.
5. Garlic Oil
Taking 12.3 mg of garlic oil daily for 16 weeks will help with hypertension. Although, we recommend using fresh garlic by adding fresh garlic to your oil.
Does Garlic Interfere With Blood Pressure Medication?
Taking garlic alongside medications to help lower blood pressure levels may cause your blood pressure levels to get too low, and cause hypotension. We recommend not taking too much garlic if you’re currently on medication and advise speaking with your health care professional for further information. You can also visit the NHS website for further assistance.
Summary
Garlic is a safe and effective remedy to help lower blood pressure levels. It can be consumed in various ways, it’s just about finding a way that works best for you. Remember, speak to your healthcare professional before adding garlic to your diet as a remedy, especially if you are on medication or have any other underlying health issues.
Journal Article
Karin Ried
1National Institute of Integrative Medicine, Melbourne, Australia
Author disclosures: K Ried, no conflicts of interest. K Ried received travel sponsorship from Wakunaga of America Co. Ltd. to attend the 2014 International Garlic Symposium.
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1
Published in a supplement to The Journal of Nutrition. Presented at the conference "2014 International Garlic Symposium: Role of Garlic in Cardiovascular Disease Prevention, Metabolic Syndrome, and Immunology," held 4–6 March 2014 at St. Regis Monarch Beach Resort in Dana Point, CA. This supplement is dedicated to our colleague and friend John A Milner. His dedication to good science and his voice for nutrition are remembered and sorely missed. The symposium was sponsored by the University of California, Los Angeles School of Medicine and the University of Florida and co-sponsored by the American Botanical Council; the American Herbal Products Association; the ASN; the Japanese Society for Food Factors; the Japan Society for Bioscience, Biotechnology, and Agrochemistry; the Japan Society of Nutrition and Food Science; and the Natural Products Association. The symposium was supported by Agencias Motta S.A.; Bionam; Eco-Nutraceuticos; Healthy U 2000 Ltd.; Magna; Mannavita Bvba; MaxiPharma; Medica Nord A.S.; Nature's Farm Pte. Ltd.; Nature Valley W.L.L.; Organic Health Ltd.; Oy Valioravinto Ab; Purity Life Health Products L.P.; PT Nutriprima Jayasakti; Vitaco Health Ltd.; Vitae Natural Nutrition; Sanofi Consumer Health Care; Wakunaga Pharmaceutical Co., Ltd.; and Wakunaga of America Co., Ltd. The Chair of the conference and Scientific Program Coordinator for the supplement publication was Matthew J Budoff, Harbor-UCLA Medical Center, Torrance, CA. Scientific Program Coordinator disclosures: MJ Budoff has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Chair of the conference. Vice-Chair and Supplement Coordinator for the supplement publication was Susan S Percival, University of Florida, Gainesville, FL. Supplement Coordinator disclosures: SS Percival has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Vice-Chair of the conference. Publication costs for this supplement were defrayed in part by the payment of page charges. This publication must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact. The opinions expressed in this publication are those of the authors and are not attributable to the sponsors or the publisher, Editor, or Editorial Board of The Journal of Nutrition.
Author Notes
Revision received:
10 October 2014
Accepted:
07 November 2014
Published:
13 January 2016
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Karin Ried, Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review, The Journal of Nutrition, Volume 146, Issue 2, February 2016, Pages 389S–396S, //doi.org/10.3945/jn.114.202192
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Abstract
Background: Garlic has been shown to have cardiovascular protective and immunomodulatory properties.
Objectives: We updated a previous meta-analysis on the effect of garlic on blood pressure and reviewed the effect of garlic on cholesterol and immunity.
Methods: We searched the Medline database for randomized controlled trials (RCTs) published between 1955 and December 2013 on the effect of garlic preparations on blood pressure. In addition, we reviewed the effect of garlic on cholesterol and immunity.
Results: Our updated meta-analysis on the effect of garlic on blood pressure, which included 20 trials with 970 participants, showed a mean ± SE decrease in systolic blood pressure (SBP) of 5.1 ± 2.2 mm Hg (P < 0.001) and a mean ± SE decrease in diastolic blood pressure (DBP) of 2.5 ± 1.6 mm Hg (P < 0.002) compared with placebo. Subgroup analysis of trials in hypertensive subjects (SBP/DBP ≥140/90 mm Hg) at baseline revealed a larger significant reduction in SBP of 8.7 ± 2.2 mm Hg (P < 0.001; n = 10) and in DBP of 6.1 ± 1.3 mm Hg (P < 0.001; n = 6). A previously published meta-analysis on the effect of garlic on blood lipids, which included 39 primary RCTs and 2300 adults treated for a minimum of 2 wk, suggested garlic to be effective in reducing total and LDL cholesterol by 10% if taken for >2 mo by individuals with slightly elevated concentrations [e.g., total cholesterol >200 mg/dL (>5.5 mmol/L)]. Garlic has immunomodulating effects by increasing macrophage activity, natural killer cells, and the production of T and B cells. Clinical trials have shown garlic to significantly reduce the number, duration, and severity of upper respiratory infections.
Conclusions: Our review suggests that garlic supplements have the potential to lower blood pressure in hypertensive individuals, to regulate slightly elevated cholesterol concentrations, and to stimulate the immune system. Garlic supplements are highly tolerated and may be considered as a complementary treatment option for hypertension, slightly elevated cholesterol, and stimulation of immunity. Future long-term trials are needed to elucidate the effect of garlic on cardiovascular morbidity and mortality.
Introduction
Traditionally, garlic has a long history as a remedy for improving strength, reducing fatigue, and increasing immunity both in prevention and treatment of infectious diseases and gastrointestinal function (1). In modern times, garlic has also been linked to improved cardiovascular health, including blood pressure, cholesterol, and other cardiovascular markers (2, 3). We updated our previously published meta-analysis on the effect of garlic on blood pressure (2) with the inclusion of several more recent trials, reviewed our meta-analysis on the effect of garlic on cholesterol, and summarized the effect of garlic on the immune system.
Effect of garlic on blood pressure.
High blood pressure is an important risk factor for cardiovascular disease and is attributed to an estimated 70% of heart attacks, strokes, and chronic heart failure, leading to 37% of cardiovascular deaths in Western countries and 13.5% globally (4, 5).3 Epidemiologic studies describe a continuous association between blood pressure and cardiovascular disease risk, suggesting a reduction in high systolic blood pressure (SBP; >140 mm Hg) by 20 mm Hg and a reduction in high diastolic blood pressure (DBP; >90 mm Hg) by 10 mm Hg to be associated with a 50% risk reduction in developing cardiovascular disease (6). Hypertension affects ∼30% of adults in Western countries, with 68 million adults in the United States alone (7). Although management of blood pressure in family practice has increased in the past 20 y, a large proportion of adults (23%) have uncontrolled blood pressure (7, 8), 9% have untreated blood pressure, and half of those treated do not achieve optimal control (7, 9).
Current medical treatment of hypertension.
Approximately 40% of hypertensive patients can achieve the target blood pressure of <140/90 mm Hg with monotherapy, independent of the type of antihypertensive medication used. Approximately 40% require combination therapy with 2 agents, and 20% need to take ≥3 antihypertensive medications to achieve blood pressure control (10). In Australia, for example, the most commonly prescribed class of antihypertensive medications (56%) are angiotensin-converting enzyme inhibitors, followed by angiotensin II receptor antagonists (27%), calcium channel blockers, diuretics, and β-blockers (11). Adverse reactions from antihypertensive medications may occur in a significant number of patients and are more likely when multiple drugs are prescribed (12). Adverse reactions include fatigue, dizziness, cough, headache, myalgia, angioedema, renal impairment, gastrointestinal upset, and hyperglycemia (12).
Garlic supplements have shown promise in lowering blood pressure in several meta-analyses (2, 13, 14), and the blood pressure–lowering action of garlic is biologically plausible. Garlic contains a number of active sulfur compounds (15) that have been reported to modulate endothelium-relaxing and -constricting factors, leading to blood pressure reduction. Specifically, garlic has been shown to stimulate the production of NO and hydrogen sulphide (H2S), both gasotransmitters leading to vasorelaxation (16–18). In addition, others reported that garlic reduced the production of the vasoconstricting factors endothelin 1 and angiotensin II (19, 20). This meta-analysis and review updates our previously published meta-analyses on the effect of garlic on blood pressure with the inclusion of recent trials.
Methods
We included trials selected in previous meta-analyses by Silagy and Neil (13), Reinhart et al. (14), and Ried et al. (2) and extended the search by using the search terms “garlic” and “hypertension” or “blood pressure” in Medline for published trials between 2008 and 2013. We included studies with placebo control groups, that used garlic-only supplements, and that reported mean SBP and/or DBP and SDs (Table 1).
TABLE 1
Characteristics of trials included in the meta-analysis of the effect of garlic on blood pressure1
Kandziora, 1988 (22) | 20/20 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 174/99 | 175/98 |
Auer et al., 1990 (23) | 24/23 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 171/102 | 161/97 |
Vorberg and Schneider, 1990 (24) | 20/20 | p | GP | Kwai | 900 | 11.7, alliin | 16 | 144.5/91 | 144/88 |
Holzgartner et al., 1992 (25) | 47/47 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 143/83 | 141/82 |
Jain et al., 1993 (26) | 20/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 129/82 | 128/83 |
DeASantos and Gruenwald, 1993 (27) | 25/27 | p | GP | Kwai | 900 | 11.7, alliin | 24 | 143/89 | 144/89 |
Kiesewetter et al., 1993 (28) | 32/32 | p | GP | Kwai | 800 | 10.4, alliin | 12 | NR/85 | NR/83 |
Saradeth et al., 1994 (29) | 31/37 | p | GP | Kwai | 600 | 7.8, alliin | 15 | 125/81 | 125/82 |
Simons et al., 1995 (30) | 28/28 | c | GP | Kwai | 900 | 11.7, alliin | 12 | 127/80 | 127/80 |
Steiner et al., 1996 (31) | 41/41 | p | AGE | Kyolic | 2400 | NR | 23 | 134/84 | 134/85 |
Adler and Holub, 1997 (32) | 12/11 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 123/83 | 118/79 |
Isaacsohn et al., 1998 (33) | 28/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 119/73 | 123/72 |
Zhang et al., 2000 (34) | 14/13 | p | GO | Cardiomax | 12.3 | NR | 16 | 114/72 | 109/64 |
Williams et al., 2005 (35) | 15/15 | c | AGE | Kyolic | 2400 | 2, SAC | 2 | 132/82 | 132/82 |
Macan et al., 2006 (36) | 22/26 | p | AGE | Kyolic | 3050 | 14.7, SAC | 12 | 122/74 | 127/82 |
Sobenin et al., 2008 (37) | 23/19 | p | GP | Allicor | 600 | 7.8, allicin pt | 12 | 143/89 | 140/88 |
Sobenin et al., 2009 (38) | G1: 30/P: 20 | p | GP | G1: Allicor | G1: 600 | G1: 7.8, allicin | 8 | G1: 156/96 | 150/94 |
G2:18 | p | GP | G2: Allicor | G2: 2400 | G2: 31.2, allicin | 8 | G2: 153/95 | 150/94 | |
G3: 16 | P | GP | G3: Kwai | G3: 900 | G3: 11.7, alliin | 8 | G3: 152/96 | 150/94 | |
Ried et al., 2010 (39) | 25/25 | p | AGE | Kyolic | 960 | 2.4, SAC | 12 | 135/74 | 141/76 |
Ried et al., 2013 (40) | G1:18/P: 17 | p | AGE | Kyolic | G1: 240 | G1: 0.6, SAC | 12 | G1: 151/77 | 149/76 |
G2:20 | p | AGE | Kyolic | G2: 480 | G2: 1.2, SAC | 12 | G2: 149/76 | 149/76 | |
G3: 19 | p | AGE | Kyolic | G3: 960 | G3: 2.4, SAC | 12 | G3: 149 /76 | 149/76 | |
Nakasone et al., 2013 (41) | HT: 23/24 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | HT: 142/91 | HT: 142/92 |
NT: 16/18 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | NT: 134/83 | NT: 134/82 |
Kandziora, 1988 (22) | 20/20 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 174/99 | 175/98 |
Auer et al., 1990 (23) | 24/23 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 171/102 | 161/97 |
Vorberg and Schneider, 1990 (24) | 20/20 | p | GP | Kwai | 900 | 11.7, alliin | 16 | 144.5/91 | 144/88 |
Holzgartner et al., 1992 (25) | 47/47 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 143/83 | 141/82 |
Jain et al., 1993 (26) | 20/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 129/82 | 128/83 |
DeASantos and Gruenwald, 1993 (27) | 25/27 | p | GP | Kwai | 900 | 11.7, alliin | 24 | 143/89 | 144/89 |
Kiesewetter et al., 1993 (28) | 32/32 | p | GP | Kwai | 800 | 10.4, alliin | 12 | NR/85 | NR/83 |
Saradeth et al., 1994 (29) | 31/37 | p | GP | Kwai | 600 | 7.8, alliin | 15 | 125/81 | 125/82 |
Simons et al., 1995 (30) | 28/28 | c | GP | Kwai | 900 | 11.7, alliin | 12 | 127/80 | 127/80 |
Steiner et al., 1996 (31) | 41/41 | p | AGE | Kyolic | 2400 | NR | 23 | 134/84 | 134/85 |
Adler and Holub, 1997 (32) | 12/11 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 123/83 | 118/79 |
Isaacsohn et al., 1998 (33) | 28/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 119/73 | 123/72 |
Zhang et al., 2000 (34) | 14/13 | p | GO | Cardiomax | 12.3 | NR | 16 | 114/72 | 109/64 |
Williams et al., 2005 (35) | 15/15 | c | AGE | Kyolic | 2400 | 2, SAC | 2 | 132/82 | 132/82 |
Macan et al., 2006 (36) | 22/26 | p | AGE | Kyolic | 3050 | 14.7, SAC | 12 | 122/74 | 127/82 |
Sobenin et al., 2008 (37) | 23/19 | p | GP | Allicor | 600 | 7.8, allicin pt | 12 | 143/89 | 140/88 |
Sobenin et al., 2009 (38) | G1: 30/P: 20 | p | GP | G1: Allicor | G1: 600 | G1: 7.8, allicin | 8 | G1: 156/96 | 150/94 |
G2:18 | p | GP | G2: Allicor | G2: 2400 | G2: 31.2, allicin | 8 | G2: 153/95 | 150/94 | |
G3: 16 | P | GP | G3: Kwai | G3: 900 | G3: 11.7, alliin | 8 | G3: 152/96 | 150/94 | |
Ried et al., 2010 (39) | 25/25 | p | AGE | Kyolic | 960 | 2.4, SAC | 12 | 135/74 | 141/76 |
Ried et al., 2013 (40) | G1:18/P: 17 | p | AGE | Kyolic | G1: 240 | G1: 0.6, SAC | 12 | G1: 151/77 | 149/76 |
G2:20 | p | AGE | Kyolic | G2: 480 | G2: 1.2, SAC | 12 | G2: 149/76 | 149/76 | |
G3: 19 | p | AGE | Kyolic | G3: 960 | G3: 2.4, SAC | 12 | G3: 149 /76 | 149/76 | |
Nakasone et al., 2013 (41) | HT: 23/24 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | HT: 142/91 | HT: 142/92 |
NT: 16/18 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | NT: 134/83 | NT: 134/82 |
1
AGE, aged garlic extract; c, crossover trial; G1–3, garlic groups 1–3; GO, garlic oil; GP, garlic powder; GPjpn, Japanese garlic powder containing egg yolk; HT, hypertensive group; NR, not reported; NT, normotensive group; p, parallel trial; P, placebo group; pt, potential; SAC, S-allylcysteine; SBP/DBP, systolic blood pressure/diastolic blood pressure.
2
Manufacturers' details of brands: Allicor: INAT-Farma, Moscow, Russia; Cardiomax: Seven Seas, Hull, United Kingdom; Dentou-ninniku-ranwo: Kenkoukazou Inc, Kagoshima, Japan; Kwai: Lichtwer Pharma GmbH, Berlin, Germany; Kyolic: Wakunaga of America Co Ltd, Mission Viejo, USA & Wakunaga Pharmaceuticals Co Ltd, Hiroshima, Japan.
TABLE 1
Characteristics of trials included in the meta-analysis of the effect of garlic on blood pressure1
Kandziora, 1988 (22) | 20/20 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 174/99 | 175/98 |
Auer et al., 1990 (23) | 24/23 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 171/102 | 161/97 |
Vorberg and Schneider, 1990 (24) | 20/20 | p | GP | Kwai | 900 | 11.7, alliin | 16 | 144.5/91 | 144/88 |
Holzgartner et al., 1992 (25) | 47/47 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 143/83 | 141/82 |
Jain et al., 1993 (26) | 20/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 129/82 | 128/83 |
DeASantos and Gruenwald, 1993 (27) | 25/27 | p | GP | Kwai | 900 | 11.7, alliin | 24 | 143/89 | 144/89 |
Kiesewetter et al., 1993 (28) | 32/32 | p | GP | Kwai | 800 | 10.4, alliin | 12 | NR/85 | NR/83 |
Saradeth et al., 1994 (29) | 31/37 | p | GP | Kwai | 600 | 7.8, alliin | 15 | 125/81 | 125/82 |
Simons et al., 1995 (30) | 28/28 | c | GP | Kwai | 900 | 11.7, alliin | 12 | 127/80 | 127/80 |
Steiner et al., 1996 (31) | 41/41 | p | AGE | Kyolic | 2400 | NR | 23 | 134/84 | 134/85 |
Adler and Holub, 1997 (32) | 12/11 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 123/83 | 118/79 |
Isaacsohn et al., 1998 (33) | 28/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 119/73 | 123/72 |
Zhang et al., 2000 (34) | 14/13 | p | GO | Cardiomax | 12.3 | NR | 16 | 114/72 | 109/64 |
Williams et al., 2005 (35) | 15/15 | c | AGE | Kyolic | 2400 | 2, SAC | 2 | 132/82 | 132/82 |
Macan et al., 2006 (36) | 22/26 | p | AGE | Kyolic | 3050 | 14.7, SAC | 12 | 122/74 | 127/82 |
Sobenin et al., 2008 (37) | 23/19 | p | GP | Allicor | 600 | 7.8, allicin pt | 12 | 143/89 | 140/88 |
Sobenin et al., 2009 (38) | G1: 30/P: 20 | p | GP | G1: Allicor | G1: 600 | G1: 7.8, allicin | 8 | G1: 156/96 | 150/94 |
G2:18 | p | GP | G2: Allicor | G2: 2400 | G2: 31.2, allicin | 8 | G2: 153/95 | 150/94 | |
G3: 16 | P | GP | G3: Kwai | G3: 900 | G3: 11.7, alliin | 8 | G3: 152/96 | 150/94 | |
Ried et al., 2010 (39) | 25/25 | p | AGE | Kyolic | 960 | 2.4, SAC | 12 | 135/74 | 141/76 |
Ried et al., 2013 (40) | G1:18/P: 17 | p | AGE | Kyolic | G1: 240 | G1: 0.6, SAC | 12 | G1: 151/77 | 149/76 |
G2:20 | p | AGE | Kyolic | G2: 480 | G2: 1.2, SAC | 12 | G2: 149/76 | 149/76 | |
G3: 19 | p | AGE | Kyolic | G3: 960 | G3: 2.4, SAC | 12 | G3: 149 /76 | 149/76 | |
Nakasone et al., 2013 (41) | HT: 23/24 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | HT: 142/91 | HT: 142/92 |
NT: 16/18 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | NT: 134/83 | NT: 134/82 |
Kandziora, 1988 (22) | 20/20 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 174/99 | 175/98 |
Auer et al., 1990 (23) | 24/23 | p | GP | Kwai | 600 | 7.8, alliin | 12 | 171/102 | 161/97 |
Vorberg and Schneider, 1990 (24) | 20/20 | p | GP | Kwai | 900 | 11.7, alliin | 16 | 144.5/91 | 144/88 |
Holzgartner et al., 1992 (25) | 47/47 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 143/83 | 141/82 |
Jain et al., 1993 (26) | 20/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 129/82 | 128/83 |
DeASantos and Gruenwald, 1993 (27) | 25/27 | p | GP | Kwai | 900 | 11.7, alliin | 24 | 143/89 | 144/89 |
Kiesewetter et al., 1993 (28) | 32/32 | p | GP | Kwai | 800 | 10.4, alliin | 12 | NR/85 | NR/83 |
Saradeth et al., 1994 (29) | 31/37 | p | GP | Kwai | 600 | 7.8, alliin | 15 | 125/81 | 125/82 |
Simons et al., 1995 (30) | 28/28 | c | GP | Kwai | 900 | 11.7, alliin | 12 | 127/80 | 127/80 |
Steiner et al., 1996 (31) | 41/41 | p | AGE | Kyolic | 2400 | NR | 23 | 134/84 | 134/85 |
Adler and Holub, 1997 (32) | 12/11 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 123/83 | 118/79 |
Isaacsohn et al., 1998 (33) | 28/22 | p | GP | Kwai | 900 | 11.7, alliin | 12 | 119/73 | 123/72 |
Zhang et al., 2000 (34) | 14/13 | p | GO | Cardiomax | 12.3 | NR | 16 | 114/72 | 109/64 |
Williams et al., 2005 (35) | 15/15 | c | AGE | Kyolic | 2400 | 2, SAC | 2 | 132/82 | 132/82 |
Macan et al., 2006 (36) | 22/26 | p | AGE | Kyolic | 3050 | 14.7, SAC | 12 | 122/74 | 127/82 |
Sobenin et al., 2008 (37) | 23/19 | p | GP | Allicor | 600 | 7.8, allicin pt | 12 | 143/89 | 140/88 |
Sobenin et al., 2009 (38) | G1: 30/P: 20 | p | GP | G1: Allicor | G1: 600 | G1: 7.8, allicin | 8 | G1: 156/96 | 150/94 |
G2:18 | p | GP | G2: Allicor | G2: 2400 | G2: 31.2, allicin | 8 | G2: 153/95 | 150/94 | |
G3: 16 | P | GP | G3: Kwai | G3: 900 | G3: 11.7, alliin | 8 | G3: 152/96 | 150/94 | |
Ried et al., 2010 (39) | 25/25 | p | AGE | Kyolic | 960 | 2.4, SAC | 12 | 135/74 | 141/76 |
Ried et al., 2013 (40) | G1:18/P: 17 | p | AGE | Kyolic | G1: 240 | G1: 0.6, SAC | 12 | G1: 151/77 | 149/76 |
G2:20 | p | AGE | Kyolic | G2: 480 | G2: 1.2, SAC | 12 | G2: 149/76 | 149/76 | |
G3: 19 | p | AGE | Kyolic | G3: 960 | G3: 2.4, SAC | 12 | G3: 149 /76 | 149/76 | |
Nakasone et al., 2013 (41) | HT: 23/24 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | HT: 142/91 | HT: 142/92 |
NT: 16/18 | p | GPjpn | Dentou-ninniku-ranwo | 188 | NR | 12 | NT: 134/83 | NT: 134/82 |
1
AGE, aged garlic extract; c, crossover trial; G1–3, garlic groups 1–3; GO, garlic oil; GP, garlic powder; GPjpn, Japanese garlic powder containing egg yolk; HT, hypertensive group; NR, not reported; NT, normotensive group; p, parallel trial; P, placebo group; pt, potential; SAC, S-allylcysteine; SBP/DBP, systolic blood pressure/diastolic blood pressure.
2
Manufacturers' details of brands: Allicor: INAT-Farma, Moscow, Russia; Cardiomax: Seven Seas, Hull, United Kingdom; Dentou-ninniku-ranwo: Kenkoukazou Inc, Kagoshima, Japan; Kwai: Lichtwer Pharma GmbH, Berlin, Germany; Kyolic: Wakunaga of America Co Ltd, Mission Viejo, USA & Wakunaga Pharmaceuticals Co Ltd, Hiroshima, Japan.
Changes in mean SBP or DBP in garlic and control groups before and after intervention were entered into the meta-analysis by using a random-effects model in Review Manager, version 5.2 (21). In addition, we performed a subgroup meta-analysis of trials in hypertensive subjects at the start of treatment (mean SBP ≥140 mm Hg or mean DBP ≥90 mm Hg) and a subgroup analysis of trials in normotensive subjects at the start of treatment (mean SBP <140 mm Hg or mean DBP <90 mm Hg).
Results
Meta-analysis
A total of 20 trials in >900 participants were identified as meeting the inclusion criteria (22–41), including 5 recent trials (37–41) that were not included in previous meta-analyses (2, 13, 14). Two trials (39, 41) included hypertensive and normotensive participants in the garlic and placebo groups. We undertook a meta-analysis that included all patients as well as a subgroup meta-analysis by baseline blood pressure (hypertensive or normotensive at baseline). Two trials (38, 40) featured 4-group, parallel, randomized controlled trials, with 3 active garlic groups of different dosages and a placebo group. In the main meta-analysis, we included only one active group compared with placebo from each of the 2 trials: the Allicor (INAT-Farma, Moscow, Russia) 400-mg group (38) and the garlic 2-capsule group (40). In addition, we tested the other active garlic groups of the 2 trials in sensitivity analysis.
Meta-analyses of all 20 trials (25 trial arms) suggested that garlic supplements significantly lower SBP by a mean (±SE) difference of 5.1 ± 2.2 mm Hg (P < 0.001; n = 19) and DBP by a mean difference of 2.6 ± 1.6 mm Hg (P < 0.001; n = 20) (Figures 1 and 2). Subgroup meta-analysis of trials and trial arms involving hypertensive participants revealed a larger significant reduction in SBP (mean difference for SBPhypertensive: −8.6 ± 2.2 mm Hg; P < 0.001; n = 10) and DBP (mean difference for DBPhypertensive: −6.1 ± 1.3 mm Hg; P < 0.001; n = 6) (Figures 3 and 4). In contrast, subgroup meta-analyses of trials involving participants with blood pressure in the prehypertensive and normal range at baseline (SBP/DBP <140/90 mm Hg) did not reveal a significant effect (mean difference for SBPnormotensive: −1.5 ± 1.9 mm Hg; n = 11; mean difference for DBPnormotensive: −0.4 ± 1.2 mm Hg; n = 14).
FIGURE 1
Forest plot showing the effect of garlic on systolic blood pressure; n = 19 trials (25 trial arms) including only 1 of 3 trial arms in 2 trials that tested different dosages of garlic compared with placebo [Sobenin 2009 (38): a2400 group; Ried 2013 (40): g2 group]. Other trial arms were tested in sensitivity analyses. Values are weighted mean differences (95% CIs) comparing changes in systolic blood pressure over time between treatment and control groups. a600, Allicor-600 mg; a2400, Allicor-2400 mg; g1, g2, g4, garlic 1-, 2-, 4-capsule group; HTSG, hypertensive subgroup; IV, inverse variance; k900, Kwai-900 mg; NTSG, normotensive subgroup.
FIGURE 2
Forest plot showing the effect of garlic on diastolic blood pressure; n = 20 trials (25 trial arms). Values are weighted mean differences (95% CIs) comparing changes in diastolic blood pressure over time between treatment and control groups. a600, Allicor-600 mg; a2400, Allicor-2400 mg; g1, g2, g4, garlic 1-, 2-, 4-capsule group; HTSG, hypertensive subgroup; IV, inverse variance; k900, Kwai-900 mg; NTSG, normotensive subgroup.
FIGURE 3
Forest plot showing the effect of garlic on systolic blood pressure in hypertensive subjects. Values are weighted mean differences (95% CIs) comparing changes in systolic blood pressure over time between treatment and control groups. a600, Allicor-600 mg; a2400, Allicor-2400 mg; g1, g2, g4, garlic 1-, 2-, 4-capsule group; HTSG, hypertensive subgroup; IV, inverse variance; k900, Kwai-900 mg; SBP, systolic blood pressure.
FIGURE 4
Forest plot showing the effect of garlic on diastolic blood pressure in hypertensive subjects. Values are weighted mean differences (95% CIs) comparing changes in diastolic blood pressure over time between treatment and control groups. a600, Allicor-600 mg; a2400, Allicor-2400 mg; DBP, diastolic blood pressure; HTSG, hypertensive subgroup; IV, inverse variance; k900, Kwai-900 mg.
The majority of trials included in the meta-analysis used standard garlic powder (GP) supplements (n = 13), 5 trials used aged garlic extract (AGE), 1 trial used garlic oil (GO), and 1 trial used an egg yolk–enriched GP. Results of subgroup analysis by type of garlic were similar between GP (n = 13) and AGE (n = 5) (Table 2). In addition, we conducted sensitivity analyses excluding the trial by Nakasone et al. (41), because this trial used a modified GP, and the influence of the egg yolk on blood pressure cannot be ruled out. These and other sensitivity analyses that used alternate trial arms with different dosages of garlic in Sobenin et al. (38) and Ried et al. (38) did not change the results appreciably (Table 2).
TABLE 2
Subgroup and sensitivity analyses1
By type of garlic | — | All2 | 19/20 | 908/940 | −5.1 ± 2.2 | −2.6 ± 1.6 |
— | GP | 12/13 | 576/640 | −5.8 ± 3.2 | −3.2 ± 2.0 | |
— | AGE | 5/5 | 233 | −4.1 ± 3.1 | 0.02 ± 2.9 | |
Sensitivity analysis | ||||||
With trial arm a600 | Sobenin et al., 2009 (38) | All | 19/20 | 920/952 | −4.9 ± 2.0 | −2.6 ± 1.7 |
With trial arm k900 | Sobenin et al., 2009 (38) | All | 19/20 | 906/938 | −4.7 ± 2.0 | −2.4 ± 1.7 |
With trial arm g1 | Ried et al., 2013 (40) | All | 19/20 | 905/941 | −4.7 ± 2.2 | −2.5 ± 1.7 |
With trial arm g4 | Ried et al., 2013 (40) | All | 19/20 | 905/942 | −4.9 ± 2.2 | −2.5 ± 1.8 |
Excluding trial | Nakasone et al., 2013 (41) | All | 18/19 | 836/900 | −5.2 ± 2.4 | −2.5 ± 1.7 |
By type of garlic | — | All2 | 19/20 | 908/940 | −5.1 ± 2.2 | −2.6 ± 1.6 |
— | GP | 12/13 | 576/640 | −5.8 ± 3.2 | −3.2 ± 2.0 | |
— | AGE | 5/5 | 233 | −4.1 ± 3.1 | 0.02 ± 2.9 | |
Sensitivity analysis | ||||||
With trial arm a600 | Sobenin et al., 2009 (38) | All | 19/20 | 920/952 | −4.9 ± 2.0 | −2.6 ± 1.7 |
With trial arm k900 | Sobenin et al., 2009 (38) | All | 19/20 | 906/938 | −4.7 ± 2.0 | −2.4 ± 1.7 |
With trial arm g1 | Ried et al., 2013 (40) | All | 19/20 | 905/941 | −4.7 ± 2.2 | −2.5 ± 1.7 |
With trial arm g4 | Ried et al., 2013 (40) | All | 19/20 | 905/942 | −4.9 ± 2.2 | −2.5 ± 1.8 |
Excluding trial | Nakasone et al., 2013 (41) | All | 18/19 | 836/900 | −5.2 ± 2.4 | −2.5 ± 1.7 |
1
Values are means ± SEs unless otherwise indicated. a600, Allicor-600 mg group; AGE, aged garlic extract; DBP, diastolic blood pressure; g1, garlic 1-capsule group; g4, garlic 4-capsule group; GP, garlic powder; k900, Kwai-900 mg group; SBP, systolic blood pressure.
2
Includes the a2400 (Allicor-2400 mg) arm of trial in reference 38 and the g2 (garlic 2)-capsule group of trial in reference 40.
TABLE 2
Subgroup and sensitivity analyses1
By type of garlic | — | All2 | 19/20 | 908/940 | −5.1 ± 2.2 | −2.6 ± 1.6 |
— | GP | 12/13 | 576/640 | −5.8 ± 3.2 | −3.2 ± 2.0 | |
— | AGE | 5/5 | 233 | −4.1 ± 3.1 | 0.02 ± 2.9 | |
Sensitivity analysis | ||||||
With trial arm a600 | Sobenin et al., 2009 (38) | All | 19/20 | 920/952 | −4.9 ± 2.0 | −2.6 ± 1.7 |
With trial arm k900 | Sobenin et al., 2009 (38) | All | 19/20 | 906/938 | −4.7 ± 2.0 | −2.4 ± 1.7 |
With trial arm g1 | Ried et al., 2013 (40) | All | 19/20 | 905/941 | −4.7 ± 2.2 | −2.5 ± 1.7 |
With trial arm g4 | Ried et al., 2013 (40) | All | 19/20 | 905/942 | −4.9 ± 2.2 | −2.5 ± 1.8 |
Excluding trial | Nakasone et al., 2013 (41) | All | 18/19 | 836/900 | −5.2 ± 2.4 | −2.5 ± 1.7 |
By type of garlic | — | All2 | 19/20 | 908/940 | −5.1 ± 2.2 | −2.6 ± 1.6 |
— | GP | 12/13 | 576/640 | −5.8 ± 3.2 | −3.2 ± 2.0 | |
— | AGE | 5/5 | 233 | −4.1 ± 3.1 | 0.02 ± 2.9 | |
Sensitivity analysis | ||||||
With trial arm a600 | Sobenin et al., 2009 (38) | All | 19/20 | 920/952 | −4.9 ± 2.0 | −2.6 ± 1.7 |
With trial arm k900 | Sobenin et al., 2009 (38) | All | 19/20 | 906/938 | −4.7 ± 2.0 | −2.4 ± 1.7 |
With trial arm g1 | Ried et al., 2013 (40) | All | 19/20 | 905/941 | −4.7 ± 2.2 | −2.5 ± 1.7 |
With trial arm g4 | Ried et al., 2013 (40) | All | 19/20 | 905/942 | −4.9 ± 2.2 | −2.5 ± 1.8 |
Excluding trial | Nakasone et al., 2013 (41) | All | 18/19 | 836/900 | −5.2 ± 2.4 | −2.5 ± 1.7 |
1
Values are means ± SEs unless otherwise indicated. a600, Allicor-600 mg group; AGE, aged garlic extract; DBP, diastolic blood pressure; g1, garlic 1-capsule group; g4, garlic 4-capsule group; GP, garlic powder; k900, Kwai-900 mg group; SBP, systolic blood pressure.
2
Includes the a2400 (Allicor-2400 mg) arm of trial in reference 38 and the g2 (garlic 2)-capsule group of trial in reference 40.
Table 3 summarizes the results of our updated meta-analysis and earlier meta-analyses on the effect of garlic on blood pressure, illustrating blood pressure status at baseline (hypertensive or normotensive) to be a strong predictor of the magnitude of blood pressure reduction. Side effects of garlic supplements, reported by approximately one-third of participants in the trials, were generally mild and included burping, flatulence, and reflux in the first few weeks of the trial (39, 40). A small percentage of the population (4–6%) may experience more severe gastrointestinal disturbances with therapeutic dosages of garlic supplements (39, 40, 42, 43). The lower tolerance of sulfur-containing foods such as garlic and onion has been linked to genetic variation in detoxification pathways of sulfur-transferase enzymes, as well as inflammatory status, and concentrations of molybdenum and vitamin B-12 (44, 45).
TABLE 3
Comparison of meta-analyses on the effect of garlic on blood pressure1
Silagy and Neil, 1994 (13) | 5 | 347 | −7.7 ± 3.4 | — | — | 5 | 347 | −5.0 ± 2.1 | — | — |
2 | 87 | −11.1 ± 6.1 | — | 2 | 87 | −6.5 ± 3.1 | — | |||
Reinhart et al., 2008 (14) | 10 | 444 | −3.9 ± 4.4 | — | — | 10 | 444 | −2.8 ± 2.4 | — | — |
3 | 139 | −16.3 ± 10.1 | — | 3 | 139 | — | −9.3 ± 4.0 | — | ||
7 | 305 | — | −0.5 ± 2.6 | 7 | 305 | — | — | −0.9 ± 1.8 | ||
Ried et al., 2008 (2) | 10 | 503 | −4.6 ± 2.8 | — | — | 11 | 567 | −2.4 ± 2.5 | — | — |
4 | 221 | — | −8.4 ± 2.8 | — | 3 | 127 | — | −7.3 ± 1.5 | — | |
6 | 282 | — | — | −2.3 ± 2.3 | 8 | 440 | — | — | −0.1 ± 1.3 | |
Ried (this article) | 19 | 908 | −5.1 ± 2.2 | — | — | 20 | 972 | −2.6 ± 1.6 | — | — |
10 | 440 | — | −8.7 ± 2.2 | — | 8 | 257 | — | −6.1 ± 1.3 | — | |
11 | 468 | — | — | −1.5 ± 1.9 | 14 | 641 | — | — | −0.4 ± 1.2 |
Silagy and Neil, 1994 (13) | 5 | 347 | −7.7 ± 3.4 | — | — | 5 | 347 | −5.0 ± 2.1 | — | — |
2 | 87 | −11.1 ± 6.1 | — | 2 | 87 | −6.5 ± 3.1 | — | |||
Reinhart et al., 2008 (14) | 10 | 444 | −3.9 ± 4.4 | — | — | 10 | 444 | −2.8 ± 2.4 | — | — |
3 | 139 | −16.3 ± 10.1 | — | 3 | 139 | — | −9.3 ± 4.0 | — | ||
7 | 305 | — | −0.5 ± 2.6 | 7 | 305 | — | — | −0.9 ± 1.8 | ||
Ried et al., 2008 (2) | 10 | 503 | −4.6 ± 2.8 | — | — | 11 | 567 | −2.4 ± 2.5 | — | — |
4 | 221 | — | −8.4 ± 2.8 | — | 3 | 127 | — | −7.3 ± 1.5 | — | |
6 | 282 | — | — | −2.3 ± 2.3 | 8 | 440 | — | — | −0.1 ± 1.3 | |
Ried (this article) | 19 | 908 | −5.1 ± 2.2 | — | — | 20 | 972 | −2.6 ± 1.6 | — | — |
10 | 440 | — | −8.7 ± 2.2 | — | 8 | 257 | — | −6.1 ± 1.3 | — | |
11 | 468 | — | — | −1.5 ± 1.9 | 14 | 641 | — | — | −0.4 ± 1.2 |
1
Values are means ± SEs unless otherwise indicated. DBP, diastolic blood pressure; SBP, systolic blood pressure.
TABLE 3
Comparison of meta-analyses on the effect of garlic on blood pressure1
Silagy and Neil, 1994 (13) | 5 | 347 | −7.7 ± 3.4 | — | — | 5 | 347 | −5.0 ± 2.1 | — | — |
2 | 87 | −11.1 ± 6.1 | — | 2 | 87 | −6.5 ± 3.1 | — | |||
Reinhart et al., 2008 (14) | 10 | 444 | −3.9 ± 4.4 | — | — | 10 | 444 | −2.8 ± 2.4 | — | — |
3 | 139 | −16.3 ± 10.1 | — | 3 | 139 | — | −9.3 ± 4.0 | — | ||
7 | 305 | — | −0.5 ± 2.6 | 7 | 305 | — | — | −0.9 ± 1.8 | ||
Ried et al., 2008 (2) | 10 | 503 | −4.6 ± 2.8 | — | — | 11 | 567 | −2.4 ± 2.5 | — | — |
4 | 221 | — | −8.4 ± 2.8 | — | 3 | 127 | — | −7.3 ± 1.5 | — | |
6 | 282 | — | — | −2.3 ± 2.3 | 8 | 440 | — | — | −0.1 ± 1.3 | |
Ried (this article) | 19 | 908 | −5.1 ± 2.2 | — | — | 20 | 972 | −2.6 ± 1.6 | — | — |
10 | 440 | — | −8.7 ± 2.2 | — | 8 | 257 | — | −6.1 ± 1.3 | — | |
11 | 468 | — | — | −1.5 ± 1.9 | 14 | 641 | — | — | −0.4 ± 1.2 |
Silagy and Neil, 1994 (13) | 5 | 347 | −7.7 ± 3.4 | — | — | 5 | 347 | −5.0 ± 2.1 | — | — |
2 | 87 | −11.1 ± 6.1 | — | 2 | 87 | −6.5 ± 3.1 | — | |||
Reinhart et al., 2008 (14) | 10 | 444 | −3.9 ± 4.4 | — | — | 10 | 444 | −2.8 ± 2.4 | — | — |
3 | 139 | −16.3 ± 10.1 | — | 3 | 139 | — | −9.3 ± 4.0 | — | ||
7 | 305 | — | −0.5 ± 2.6 | 7 | 305 | — | — | −0.9 ± 1.8 | ||
Ried et al., 2008 (2) | 10 | 503 | −4.6 ± 2.8 | — | — | 11 | 567 | −2.4 ± 2.5 | — | — |
4 | 221 | — | −8.4 ± 2.8 | — | 3 | 127 | — | −7.3 ± 1.5 | — | |
6 | 282 | — | — | −2.3 ± 2.3 | 8 | 440 | — | — | −0.1 ± 1.3 | |
Ried (this article) | 19 | 908 | −5.1 ± 2.2 | — | — | 20 | 972 | −2.6 ± 1.6 | — | — |
10 | 440 | — | −8.7 ± 2.2 | — | 8 | 257 | — | −6.1 ± 1.3 | — | |
11 | 468 | — | — | −1.5 ± 1.9 | 14 | 641 | — | — | −0.4 ± 1.2 |
1
Values are means ± SEs unless otherwise indicated. DBP, diastolic blood pressure; SBP, systolic blood pressure.
Despite the general medical advice, evidence is weak for garlic supplements, including GP, GO, and AGE, to cause harmful interactions if taken in addition to blood-thinning, blood sugar–regulating, or anti-inflammatory medications (36, 46, 47). Physicians and patients need to be mindful, however, of a potentially harmful interaction of garlic with protease inhibitors in antiretroviral therapy (46).
Other cardiovascular-protective effects of garlic
Effect of garlic on cholesterol.
Several meta-analyses demonstrated a cholesterol-lowering effect of garlic supplements. A recent and most comprehensive meta-analysis including 39 trials and almost 2300 subjects suggested that garlic moderately but significantly lowers total serum cholesterol (−17 ± 6 mg/dL) and LDL cholesterol (9 ± 6 mg/dL) if taken for >2 mo by patients with slightly elevated cholesterol (>200 mg/dL, >5.5 mmol/L) (3). The 8% reduction in serum cholesterol is of clinical relevance and has been associated with a 38% risk reduction in coronary events at age 50 y (48, 49). Trials in the meta-analysis used GP (n = 31), GO (n = 6), AGE (n = 6), and raw garlic (n = 3). Nine of the trials ran between 2 and 8 wk, and 30 trials lasted >8 wk.
Side effects with garlic supplements were minimal, with one-third of participants complaining about odor and 7% experiencing mild gastrointestinal discomfort (3). In comparison, mild gastrointestinal complaints were also described by 7% in the placebo group. In contrast, current standard pharmacologic treatment for cholesterol with statins may trigger adverse effects in a considerable number of patients, including myalgia (muscle pain), muscle weakness, neuropathy, cognitive impairment, mood disorders, anxiety, and an increased risk of diabetes (50–53).
Cholesterol is essential for normal body functions that include preserving the integrity of cell membranes, facilitating cell signaling, maintaining the myelin sheath, and synthesizing steroid hormones, vitamin D, and coenzyme Q10. The inhibition of cholesterol synthesis by statin drugs may interfere with these essential pathways, resulting in detrimental effects for some patients (50–53).
In addition, there is cumulative evidence to suggest that lipoproteins also have a role in the immune response to infection as part of the innate immune system (54). Although HDL cholesterol plays a role in the immune response to viral and parasitic infections, LDL cholesterol appears to be involved in the host defense to bacterial infections (54). Oxidized LDL cholesterol, on the other hand, has been associated with plaque formation and increased risk of heart attack and stroke when accumulated in the endothelium (55). The oxidization of LDL cholesterol may be generated by free radicals through dietary factors, such as consumption of trans fats, deep-fried foods, smoking, or the presence of high blood sugar (56). However, chemical analyses have found oxidized LDL cholesterol to consist of many heterogeneous components, suggesting multiple origins, possibly including interaction with pathogens and their toxins (57).
Because of the many purposes of cholesterol and serum lipoproteins in the human body, some of which are undoubtedly still incompletely understood, cholesterol concentrations need to be adjusted with care. Indeed, there is a growing list of clinical trials in which interference with serum cholesterol led to disappointing—and in some cases detrimental—results (58).
In contrast, garlic supplements have been linked to moderate reduction in cholesterol concentrations, therefore providing an alternative cholesterol-regulating agent with a higher safety profile than statins in patients with slightly elevated cholesterol.
Effect of garlic on immunity.
Historically, garlic has been used for its anti-infective activities, immune-boosting properties, and general strengthening actions (1). In vitro and cell culture studies showed garlic to have antibacterial, antivirus, antifungal, and antiparasitic properties. Garlic was shown to stall growth of food pathogens such as Salmonella, Listeria, Escherichia coli, the stomach bacteria Helicobacter pylori, and the tuberculosis-causing pathogen Mycobacterium tuberculosis (59, 60). In addition, garlic inhibits biofilm formation by bacterial pathogens from burn wounds (61). Garlic's antiviral actions include the human rhinovirus, cytomegalovirus, herpes simplex, and influenza (62). Garlic is effective in the treatment of common yeast and fungal infections such as Candida albicans and Aspergillus flavus (63). Furthermore, garlic shows promise as an antiparasitic agent, helping in the treatment of Cryptosporidium, Toxoplasma, Giardia, and Plasmodium (64).
Garlic is a prebiotic, containing fructans and oligosaccharides, which stimulate the growth of “friendly” bacteria in the digestive tract (65, 66) that in turn make up the microbiome, which contributes to ∼80% of the immune system (67). Garlic was shown to stimulate activation of the humoral and inert immune system, including the activation of macrophages by NO production and T and B cell production (68–70).
Clinical trials have shown garlic to have a beneficial effect in the prevention, duration, and severity of upper respiratory infections. A randomized, double-blind, placebo-controlled trial in 146 participants testing the effect of 180 mg GP/d over 3 mo found a 37% reduction in the number of colds (garlic compared with placebo: n = 24 compared with n = 65; P < 0.001) and a 30% reduction in the duration of illness (garlic compared with placebo: 1.5 compared with 5 d; P < 0.001) in the group taking garlic compared with the placebo group (71).
A recent trial in 120 participants that tested the effect of 2.56 g AGE/d over 3 mo found a 61% reduction in the number of days (garlic compared with placebo: 53 compared with 126 d; P < 0.001) and a 21% reduction in symptoms (garlic compared with placebo: 584 compared with 126; P < 0.001) (70). In this trial, a significant increase in γδ-T cells (P = 0.039) and NK cells (P = 0.043) was shown in the garlic group after 45 d compared with placebo.
In addition, garlic contains the immunomodulatory proteins lectins or agglutinins [allium sativum agglutinin (ASA) I and ASA II] (66, 72). Furthermore, garlic was shown to reduce inflammatory markers, including C-reactive protein and TNF-α (73, 74). A high concentration of inflammatory C-reactive protein has been associated with greater odds of developing coronary artery disease (OR: 1.45; 95% CI: 1.25, 1.68) (75). Therefore, the beneficial effects of garlic on the immune system, including C-reactive protein and cytokines such as ILs and TNF-α, are also associated with improved cardiovascular health.
In conclusion, garlic has the potential to improve cardiovascular health on several levels. First, there is consistent evidence that garlic supplements lower blood pressure in hypertensive individuals. Second, there is strong evidence that garlic modulates cholesterol concentrations when slightly elevated. Third, garlic has several immune system–enhancing properties that directly and indirectly benefit cardiovascular health. Garlic supplements have a high safety profile and are generally well tolerated. Therefore, garlic supplements may be considered as an alternative or complementary treatment in addition to standard medication for cardiovascular health. Further long-term trials are needed to elucidate the effect of garlic supplementation on cardiovascular morbidity and mortality.
Acknowledgments
The sole author read and approved the final version of the manuscript.
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Abbreviations
AGE
ASA
allium sativum agglutinin
DBP
GO
GP
SBP
Author notes
1
Published in a supplement to The Journal of Nutrition. Presented at the conference "2014 International Garlic Symposium: Role of Garlic in Cardiovascular Disease Prevention, Metabolic Syndrome, and Immunology," held 4–6 March 2014 at St. Regis Monarch Beach Resort in Dana Point, CA. This supplement is dedicated to our colleague and friend John A Milner. His dedication to good science and his voice for nutrition are remembered and sorely missed. The symposium was sponsored by the University of California, Los Angeles School of Medicine and the University of Florida and co-sponsored by the American Botanical Council; the American Herbal Products Association; the ASN; the Japanese Society for Food Factors; the Japan Society for Bioscience, Biotechnology, and Agrochemistry; the Japan Society of Nutrition and Food Science; and the Natural Products Association. The symposium was supported by Agencias Motta S.A.; Bionam; Eco-Nutraceuticos; Healthy U 2000 Ltd.; Magna; Mannavita Bvba; MaxiPharma; Medica Nord A.S.; Nature's Farm Pte. Ltd.; Nature Valley W.L.L.; Organic Health Ltd.; Oy Valioravinto Ab; Purity Life Health Products L.P.; PT Nutriprima Jayasakti; Vitaco Health Ltd.; Vitae Natural Nutrition; Sanofi Consumer Health Care; Wakunaga Pharmaceutical Co., Ltd.; and Wakunaga of America Co., Ltd. The Chair of the conference and Scientific Program Coordinator for the supplement publication was Matthew J Budoff, Harbor-UCLA Medical Center, Torrance, CA. Scientific Program Coordinator disclosures: MJ Budoff has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Chair of the conference. Vice-Chair and Supplement Coordinator for the supplement publication was Susan S Percival, University of Florida, Gainesville, FL. Supplement Coordinator disclosures: SS Percival has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Vice-Chair of the conference. Publication costs for this supplement were defrayed in part by the payment of page charges. This publication must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact. The opinions expressed in this publication are those of the authors and are not attributable to the sponsors or the publisher, Editor, or Editorial Board of The Journal of Nutrition.
© 2016 American Society for Nutrition
© 2016 American Society for Nutrition
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